Highlights of the Cancer Chemoprevention
studies in China

New retinoids have been synthesized and screened in the search for Chemopreventive agents of cancer. N-4-(Carboxyphenyl) retinamide showed a significant inhibitory effect on carcinogenesis of cancers in the buccal pouch of hamsters and in the forestomach of mice.

Clinical studies have demonstrated that N-4-(Carboxyphenyl) retinamide is effective against oral leukoplakia, and dysplasia of the uterine cervix and stomach.

Field studies among a population at high risk for esophageal cancer in Linxian County, Henan Province, revealed that N-4-(ethoxycarbophenyl) retinamide decreased that incidence of this cancer.

Qidong County is a high-risk area for hepatoma in China.

This has been correlated to the low levels of selenium in the blood
of the residents as well as in grain grown in the area.

S.Y. Yu, W.G.Li, Y.J. Zhu, et. Al. (BiolTrace Element Res. 1985; 7:22-26)
reported that the administration of selenium inhibited the incidence of hepatoma
induced by aflatoxin B in rats and ducks.

Experimental studies demonstrated that green tea extract inhibited
12-0-tetradecanoylphorbol-3-acetate.

Garlic has been used for thousands of years in Chinese cooking and folk medicine.

Epidemiological studies show that the dietary intake of garlic is inversely related to gastric cancer incidence in Shandong Province.

Han J. Highlights of the cancer chemopreventive studies in China.
Prev Med 1993 Sep;22(5): 712-22.

Index of Articles