The Effect of Folate and Cobalamin Vitamin B12
on Osteoarthritic Hands.
 

Abstract:

OBJECTIVE: Historically diet and arthritis have been cause/effect associated but the idea is controversial with little evidence that specific diet components are effective treatment. This controlled, double-blinded, crossover study reports the effect of folate and cobalmin(B-12) supplements in 26 humans diagnosed for an average 5.7 years with idiopathic osteoarthritis of the hands who had medicated by prescribed nonsteroidal anti-inflamatory drugs (NSAID).

METHODS: Subjects entered the study after a 10-day washout period from use of all anti-arthritis drugs, vitamins, and minerals. They were randomly allocated to consume daily 6400 micrograms folate or 6400 micrograms folate plus 20 micrograms cobalmin(B-12) or lactose placebo each for 2 months within self-selected diets. Pain was to be medicated by acetaminophem as needed, and at the end of each phase they returned for assessment and dispensing of the next treatment. Serum folate and cobalmin, red blood cell folate, blood smears, diet records, standard rheumatology assessment and hand grip measurements were reviewed and statistically analyzed.

RESULTS:   For all subjects mean right and left hand grip values were higher with combined cobalmin-folate ingestion than with other vitamin supplements and were equivalent to NSAID use.
Number of tender hand joints were greater with use of NSAID than with use of cobalmin-folate. Side effects with the vitamin combination were none; side effects of NSAID are many, and the cost of vitamins and acetaminophen also is lower.

CONCLUSION:  The limited number of subjects in this study demonstrates that ingestion of a prescribed cobalmin-folate supplement and acetaminophen as needed resulted in positive outcomes.


Flynn, MA; Irvin W; Krause G, Jour AmerColl Nutr 13(4) August (1994): 351-6
 

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