Xtra-Cell PgP ™
Supports Healthy Cell Membranes and Normal Blood Vessel Growth




DESCRIPTION
Xtra-Cell™ PgP capsules, contain a synergistic combination of herbs, minerals and plant extracts designed to support normal functioning of cell membranes and normal blood vessel growth.

FUNCTIONS
Xtra-Cell PgP provides support to cell membranes and blood vessels through two actions: modification of P-glycoproteins (P-gp) activity and support of normal angiogenesis (blood vessel growth). P-gp proteins are found in the cell membrane and can act as pumps, moving certain pharmacotherapeutic molecules out of the cell membrane.

The activity of P-gp pumps can affect the ability of certain molecules to remain in the cell, thus potentially decreasing the efficacy of therapeutic agents and increasing the body’s resistance to immune-supportive therapies. Angiogenesis is a natural process by which new blood vessels are formed and grow to supply oxygen and nutrients to cells.* Angiogenesis is a complex process that is regulated at the cellular level with a balance between factors that are proangiogenic and factors that are anti-angiogenic.

Disturbances in this balance can lead to processes that favor proangiogenic factors and can lead to a proliferation of microvessel formation that can effect the health of a tissue.*

The ingredients in Xtra-Cell PgP are thought to play important roles in maintaining proper cell membrane and blood vessel health.

Green Tea
Scientists have identified numerous phytochemicals including polyphenols, methylxanthines, flavonoids, and triterpenoid saponins in green tea. The polyphenols contained in tea, the majority of which are catechins, appear to provide the primary health promoting benefits associated with green tea consumption. Catechin, epicatechin (EC), epigallocatechin (EGC), and most notably epigallocatechin gallate (EGCG) act as antioxidants and support immune function and cardiovascular health. In vitro, these nutrients have been shown to inhibit cell growth and induce apoptosis, as well as support healthy angiogenic and p-gp activity.*

Turmeric
Studies have shown that curcumin, a naturally occurring biologically active group of compounds from Curcuma longa (Turmeric), can function as efficient antioxidants and can help regulate the body’s normal response to inflammatory processes, as well as play important roles in maintaining healthy angiogenesis and p-gp activity.*

Milk Thistle(Silymarin)
Silymarin can provide protection to the liver by acting as an important component of the liver’s antioxidant defense. The liver generates potentially damaging, toxic free radicals and reactive oxygen species as a result of its normal metabolic and detoxifying functions. Left unchecked, these radicals can initiate a chain reaction of lipid peroxidation, causing damage to cell structure and interfering with normal cell functions.

Soybeans
Isoflavones, a class of phytoestrogens found in soy, are plant-derived compounds that are similar in structure and/or function to animal estrogens. Genistein and daidzein are two predominant isoflavones found in soy. Epidemiological studies have found that individuals with high soy intake often enjoy certain health advantages. Numerous laboratory and clinical studies, investigating the health benefits of soy products, have identified soy isoflavones as key components responsible for the health benefits associated with soy foods. Numerous studies indicate that isoflavones may support the immune system, inhibit angiogenesis, and protect against oxidative damage as antioxidants.

Flax seed
Flax seed is the richest source of lignans, a class of diphenolic molecules most often found in vegetables and fruits. Studies of lignans have shown that they can play important roles in supporting the body’s normal sex hormone metabolism, as well as normal functioning of cell proliferation and angiogenesis.*

Minerals and Amino Acids
Selenium is an essential cofactor of glutathione peroxidase, a potent antioxidant and plays important roles in maintaing normal cell growth. Copper regulates iron metabolism and also helps to activate superoxide dismutase. Zinc is important for growth, immune system function, protein synthesis, antioxidant mechanisms, and wound healing. Amino acids are the building blocks for all body proteins, structural proteins that build muscle, connective tissues, bones and other structures, and functional proteins in the form of thousands of metabolically active enzymes. Amino acids provide the body with the nitrogen that is essential for growth and maintenance of all tissues and structures.*

INDICATIONS
Xtra-Cell PgP may be a useful dietary supplement for those who wish to support healthy cell membranes and normal blood vessel growth.


FORMULA
2 capsules contain:

Zinc
(from zinc chelazome) ............................................ 15 mg

Selenium
(from high selenium yeast) ................................... 200 mcg

Copper
(from copper chelazome) ..................................... 700 mcg

Green Tea extract (leaf) ........................................250 mg
(standardized to 75% polyphenols and 25% EGCG)

Turmeric root extract.............................................200 mg
(standardized to 95% curcuminoids)

Milk thistle fruit extract ......................................... 200 mg
(Standardized to 80% silymarin

Soy bean extract ....................................................65 mg
(standardized to 40% isoflavones and 20% genistein)

Flaxseed extract .................................................... 35 mg

Proprietary Blend ................................................. 274 mg
Glycine, L-Glutamine, L-Leucine, L-Threonine, L-aspartate, L-Valine, L-Isoleucine, L-Glutamate, L-Alanine

SUGGESTED USE
As a dietary supplement, take 2 capsules per day, preferably with meals or as directed by your health care professional.

SIDE EFFECTS/WARNINGS
May not be suitable for children under 12 years of age, pregnant or nursing women, or persons who recently had a heart attack. Consult a healthcare professional before use.

STORAGE
Keep out of reach of children.

REFERENCES
Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med 1997;29:95-120. Combs GF Jr, et al. Chemopreventive agents: selenium. Pharmacol Ther. 1998;79(3):179-92. Fujiki H et al. Cancer inhibition by green tea. Mutat Res 1998;402(1-2):307-10. Garg AK, Buchholz TA, Aggarwal BB. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: A short review. Life Sci. 2006 Jan 12 Prasad AS. Zinc and immunity. Mol Cell Biochem. 1998;188(1-2):63-9. Saleem M, Kim HJ, Ali MS, Lee YS. An update on bioactive plant lignans. Nat Prod Rep. 2005 Dec;22(6):696-716. Zi, X et al. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promotor TNF alpha. Biochem Biophys Res Commun 1997;239(1):334-339.

*These statements have not been evaluated
by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

† Extraction process covered under U.S. patent number 5,985,839
 

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